Protocols – Diagnosis, Treatment and Follow-Up
The data specified below were provided by the hospitals.
It is the mother’s responsibility to contact the hospital in which she intends to give birth and check the up-to-date protocol
No information received
No information received
Postnatal Diagnosis Protocol:
Type of newborn test to identify infection
Urine test
The protocol of the newborn tests when there is known infection in amniotic fluid
During hospitalization, the following are performed: Blood tests, brain ultrasound, eye fundus examination, BERA test will be performed at the Lin Medical Center or at the patient’s HMO, initial consultation with a pediatric infectious diseases specialist is conducted in the department.
The protocol of the newborn tests when there is known maternal infection during pregnancy, but amniocentesis was not performed
Yes
Newborn saliva/urine test when there is known negative amniocentesis
Yes
The follow-up and treatment protocol of asymptomatic and symptomatic CMV children:
The follow-up protocol is not conducted at Carmel Medical center. The newborns are referred to infectious disease clinics that are responsible for the follow-up and treatment of infants with congenital CMV infection.
No information received
No information received
Postnatal Diagnosis Protocol:
Type of newborn test to identify infection
Saliva test + urine test if the saliva test is positive
The protocol of the newborn tests when there is known infection in amniotic fluid
During hospitalization, the following are performed: Blood tests, brain ultrasound, eye fundus examination, BERA test
The protocol of the newborn tests when there is known maternal infection during pregnancy, but amniocentesis was not performed
No information received
Newborn saliva/urine test when there is known negative amniocentesis
No information received
The follow-up and treatment protocol of asymptomatic CMV children:
Until what age is follow-up conducted?
No information received
What tests are performed in the protocol and how frequently?
No information received
The follow-up and treatment protocol of asymptomatic CMV children:
Until what age is follow-up conducted?
No information received
What tests are performed in the protocol and how frequently?
No information received
Duration of drug therapy
No information received
Postnatal Diagnosis Protocol:
Type of newborn test to identify infection
Urine test
The protocol of the newborn tests when there is known infection in amniotic fluid
During hospitalization, the following are performed: Blood tests, brain ultrasound, eye fundus examination, consultation with pediatric infectious diseases specialist, a BERA test appointment will be scheduled.
Upon discharge, appointments will also be scheduled for Otolaryngology Clinic, Neurology Clinic and Pediatric Infectious Diseases Clinic.
.The protocol of the newborn tests when there is known maternal infection during pregnancy, but amniocentesis was not performed
The tests are performed only if the urine test is positive. If a newborn was discharged home and the test comes back positive, the staff assures the tests are completed as soon as possible.
Newborn saliva/urine test when there is known negative amniocentesis
Yes
The follow-up and treatment protocol of asymptomatic CMV children:
Until what age is follow-up conducted?
No information received
What tests are performed in the protocol and how frequently?
No information received
The follow-up and treatment protocol of symptomatic CMV children:
Until what age is follow-up conducted?
No information received
What tests are performed in the protocol and how frequently?
No information received
Duration of drug therapy
No information received
Postnatal Diagnosis Protocol:
Type of newborn test to identify infection
Urine test
The protocol of the newborn tests when there is known infection in amniotic fluid
During hospitalization, the following are performed: Blood tests, brain ultrasound, eye fundus examination, BERA test
The protocol of the newborn tests when there is known maternal infection during pregnancy, but amniocentesis was not performed
Mostly Yes, with family consent
Newborn saliva/urine test when there is known negative amniocentesis
Yes
The follow-up and treatment protocol of asymptomatic CMV children:
Until what age is follow-up conducted?
No information received
What tests are performed in the protocol and how frequently?
No information received
The follow-up and treatment protocol of symptomatic CMV children:
Until what age is follow-up conducted?
No information received
What tests are performed in the protocol and how frequently?
No information received
Duration of drug therapy
No information received
Postnatal Diagnosis Protocol:
Type of newborn test to identify infection
Urine test
The protocol of the newborn tests when there is known infection in amniotic fluid
During hospitalization, the following are performed: Blood tests, brain ultrasound, eye fundus examination, BERA test, consultation with a pediatrician who is a CMV specialist
The protocol of the newborn tests when there is known maternal infection during pregnancy, but amniocentesis was not performed
Efforts to perform all the tests during hospitalization, even if the results of the urine tests have not arrived yet.
Newborn saliva/urine test when there is known negative amniocentesis
Yes
Follow-up on symptomatic and asymptomatic CMV children is carried out at the Schneider Medical Center
The follow-up and treatment protocol of asymptomatic CMV children:
Until what age is follow-up conducted?
Age 5
What tests are performed in the protocol and how frequently?
Follow-up with blood tests during drug therapy.
BERA test every six months until the age of two years, and then a behavioral hearing test until the age of 5.
At the age of 9 months: a developmental neurological assessment.
The follow-up and treatment protocol of symptomatic CMV children:
Until what age is follow-up conducted?
Age 5
What tests are performed in the protocol and how frequently?
Follow-up with blood tests during drug therapy.
BERA test every six months until the age of two years and then a behavioral hearing test until the age of 5.
At the age of 9 months: a developmental neurological assessment.
Duration of drug therapy
Six months to one year, on a case by case basis
Postnatal Diagnosis Protocol:
Type of newborn test to identify infection
Saliva test + urine test if necessary.
In the case of a woman with high AVIDITY (over 40, depending on the lab) and positive or borderline positive IGM, the hospital will not perform a saliva test on the fetus
The protocol of the newborn tests when there is known infection in amniotic fluid
During hospitalization, the following are performed: Blood tests, brain ultrasound, eye fundus examination, BERA test, abdominal ultrasound and examination by cardiologist.
The protocol of the newborn tests when there is known maternal infection during pregnancy, but amniocentesis was not performed
The tests are performed during hospitalization.
Newborn saliva/urine test when there is known negative amniocentesis
No. Only in exceptional cases
The follow-up and treatment protocol of asymptomatic CMV children:
Until what age is follow-up conducted?
No information received
What tests are performed in the protocol and how frequently?
No information received
The follow-up and treatment protocol of symptomatic CMV children:
Until what age is follow-up conducted?
No information received
What tests are performed in the protocol and how frequently?
No information received
Duration of drug therapy
No information received
Postnatal Diagnosis Protocol:
Type of newborn test to identify infection
Urine test
The protocol of the newborn tests when there is known infection in amniotic fluid
During hospitalization, the following are performed: Blood tests, brain ultrasound, eye fundus examination, a BERA test appointment is scheduled during hospitalization
The protocol of the newborn tests when there is known maternal infection during pregnancy, but amniocentesis was not performed
The results of the urine tests arrive within 24 hours, so in most cases there is enough time to carry out the entire tests’ protocol as carried out in the case of a positive amniocentesis.
Newborn saliva/urine test when there is known negative amniocentesis
Yes
Follow-up on symptomatic and asymptomatic CMV children is carried out at the Dana-Dwek Children’s Hospital
No information received
Postnatal Diagnosis Protocol:
Type of newborn test to identify infection
Saliva test + urine test if the saliva test is positive
The protocol of the newborn tests when there is known infection in amniotic fluid
During hospitalization, the following are performed: Blood tests, brain ultrasound, eye fundus examination, BERA test. If there is not enough time to carry out the tests, an appointment is scheduled as soon as possible after the hospitalization.
The protocol of the newborn tests when there is known maternal infection during pregnancy, but amniocentesis was not performed
The tests are performed only if the urine test is positive. If a newborn was discharged home and their test is positive, the staff makes sure the tests are completed as soon as possible.
Newborn saliva/urine test when there is known negative amniocentesis
Yes
The follow-up and treatment protocol of asymptomatic CMV children:
Until what age is follow-up conducted?
Age 5
What tests are performed in the protocol and how frequently?
Close follow-up until the age of 18 months:
Brain ultrasound is usually performed once.
BERA tests every 2-3 months.
As of the age of 18 months, a hearing test once every six months (not BERA).
Eye fundus examination at birth and at the age of six months.
The follow-up and treatment protocol of symptomatic CMV children:
The follow-up and treatment protocol of symptomatic CMV children:
Up to the age of 5. According to the symptoms, may be longer.
What tests are performed in the protocol and how frequently?
Similar to the follow-up with the asymptomatic children, lower number of BERA tests.
Duration of drug therapy
Usually one year
The follow-up and treatment protocol of asymptomatic CMV children:
Until what age is follow-up conducted?
At least until the age of 5
What tests are performed in the protocol and how frequently?
In the first year of life, BERA test every 4 months.
In the second year of life, BERA test every six months.
From the age of two years, a behavioral hearing test every six months.
Check-up by infectious diseases specialist will take place after every hearing test until the age of two years.
After the age of two years, updates via email.
The follow-up and treatment protocol of symptomatic CMV children:
Until what age is follow-up conducted?
At least until the age of 5
What tests are performed in the protocol and how frequently?
In the first year of life, BERA test every 4 months.
In the second year of life, BERA test every six months.
From the age of two years, a behavioral hearing test every six months.
Blood tests for patients under treatment.
Check-up by infectious diseases specialists will take place after each hearing test.
Duration of drug therapy
One year. First 3 months twice a day and then once a day
Postnatal Diagnosis Protocol:
Type of newborn test to identify infection
Saliva test + urine test if the saliva test is positive.
The protocol of the newborn tests when there is known infection in amniotic fluid
During hospitalization, the following are performed: Blood tests, brain ultrasound, eye fundus examination, schedule BERA test within two weeks, schedule consultation with a pediatrician who is a CMV specialist within 3-4 weeks
The protocol of the newborn tests when there is known maternal infection during pregnancy, but amniocentesis was not performed
The tests are performed only if the urine test is positive. If a newborn was discharged home and the test comes back positive, the staff makes sure the tests are completed as soon as possible.
Newborn saliva/urine test when there is known negative amniocentesis
Yes.
The follow-up and treatment protocol of asymptomatic CMV children:
Until what age is follow-up conducted?
Until the age of 12 months at the clinic and up to the age of 6 at the Speech and Hearing Institute
What tests are performed in the protocol and how frequently?
The first hearing test BERA.
Later, a behavioral test + TEAOE (cochlear echoes) – every 3 months during the first year, in the second and third year – every six months and then up to the age of 6 years – once a year.
If the test is abnormal – a BERA is performed under sedation.
During the first year, check-up at the CMV clinic after each hearing test (every 3 months).
The follow-up and treatment protocol of symptomatic CMV children:
Until what age is follow-up conducted?
Until the age of 12 months at the clinic and up to the age of 6 at the Speech and Hearing Institute
What tests are performed in the protocol and how frequently?
In addition to the hearing tests – during the drug therapy, blood counts should be performed once every two weeks and appointments every 6-8 weeks to adjust the dosage.
Duration of drug therapy
Six months (except for special cases)
No information received
Postnatal Diagnosis Protocol:
Type of newborn test to identify infection
Saliva test + urine test if the saliva test is positive, or if the amniocentesis is positive
The protocol of the newborn tests when there is known infection in amniotic fluid
During hospitalization, the following are performed: Blood tests, brain ultrasound, eye fundus examination, BERA test.
The protocol of the newborn tests when there is known maternal infection during pregnancy, but amniocentesis was not performed
The tests are performed if the saliva and urine are positive.
Newborn saliva/urine test when there is known negative amniocentesis
Yes.
The follow-up and treatment protocol of asymptomatic CMV children:
Until what age is follow-up conducted?
Follow-up at the Pediatric Infectious Diseases Clinic up to the age of 10.
What tests are performed in the protocol and how frequently?
Eye fundus examination between the age of six months and one year.
The first hearing test is BERA.
In the first two years, a hearing test and clinic follow-up once every 3 months, and then once a year.
The follow-up and treatment protocol of symptomatic CMV children:
Until what age is follow-up conducted?
Follow-up at the Pediatric Infectious Diseases Clinic up to the age of 10.
What tests are performed in the protocol and how frequently?
At the beginning, close follow-up at the clinic and blood tests.
Later, follow-up takes place once every three months.
Duration of drug therapy
Mostly six months.
Postnatal Diagnosis Protocol:
Type of newborn test to identify infection
Saliva test + urine test if the saliva test is positive, or if the amniocentesis is positive.
The protocol of the newborn tests when there is known infection in amniotic fluid
During hospitalization, the following are performed: Blood tests, brain ultrasound, eye fundus examination, BERA test.
The protocol of the newborn tests when there is known maternal infection during pregnancy, but amniocentesis was not performed
The tests are performed if the saliva and urine are positive.
Newborn saliva/urine test when there is known negative amniocentesis
Yes.
The follow-up and treatment protocol of asymptomatic CMV children:
Until what age is follow-up conducted?
Follow-up at the Pediatric Infectious Diseases Clinic up to the age of 10.
What tests are performed in the protocol and how frequently?
Eye fundus examination between the age of six months and one year.
The first hearing test is BERA.
In the first two years, a hearing test and clinic follow-up once every 3 months, and then once a year.
The follow-up and treatment protocol of symptomatic CMV children:
Until what age is follow-up conducted?
Follow-up at the Pediatric Infectious Diseases Clinic up to the age of 10.
What tests are performed in the protocol and how frequently?
At the beginning, close follow-up at the clinic and blood tests.
Later, follow-up takes place once every three months.
Duration of drug therapy
Mostly six months.
Postnatal Diagnosis Protocol:
Type of newborn test to identify infection
Urine test
The protocol of the newborn tests when there is known infection in amniotic fluid
During hospitalization, efforts should be made to perform the following tests: Blood tests, brain ultrasound, eye fundus examination, a BERA test appointment will be scheduled later.
The protocol of the newborn tests when there is known maternal infection during pregnancy, but amniocentesis was not performed
For the most part, the tests are performed only if the urine test is positive. Sometimes, testing is started early, primarily brain ultrasound and eye fundus examination
Newborn saliva/urine test when there is known negative amniocentesis
Yes.
The follow-up and treatment protocol of asymptomatic CMV children:
Until what age is follow-up conducted?
Age 6-7
What tests are performed in the protocol and how frequently?
Hearing follow-up at an audiology institute. As the child grows older, the time gap between tests is greater.
Routine follow-up with pediatrician.
The follow-up and treatment protocol of symptomatic CMV children:
Until what age is follow-up conducted?
Age 6-7.
.What tests are performed in the protocol and how frequently
Audiological follow-up until the age of 6-7.
Development and neurology tests and physical therapy sessions as necessary.
Duration of drug therapy
Treatment up to the age of six months as recommended in the literature.
Postnatal Diagnosis Protocol:
Type of newborn test to identify infection
For the most part, a urine test, a saliva test only if there is a technical difficulty to collect urine.
The protocol of the newborn tests when there is known infection in amniotic fluid
During hospitalization, the following are performed: Blood tests, brain ultrasound, eye fundus examination. BERA test within 2 week to month after delivery
The protocol of the newborn tests when there is known maternal infection during pregnancy, but amniocentesis was not performed
For the most part, the result will be received when the infant is already home, and then it will be necessary to complete a number of tests. If the result is received during hospitalization, further testing will take place during hospitalization.
Newborn saliva/urine test when there is known negative amniocentesis
Yes.
The follow-up and treatment protocol of asymptomatic and symptomatic CMV children:
The infant is referred to further follow-up and investigation at Tel-Hashomer Hospital.
Diagnosis and hearing follow up will be performed at the Hearing, Language and Speech Institute at Assuta Hospital Ashdod according to the following protocol:
BERA test within 2 weeks to month after delivery.
Later, a behavioral test + TEAOE (cochlear echoes) – every 3 months during the first year, in the second and third year – every six months and then up to the age of 6 years – once a year.
Postnatal Diagnosis Protocol:
Type of newborn test to identify infection
Saliva test + urine test if the saliva test is positive.
The protocol of the newborn tests when there is known infection in amniotic fluid
The results of the tests are received within one-two days. During hospitalization, brain ultrasound, eye fundus examination and hearing screening test are performed. The newborn is required to complete the full BERA test in an outpatient setting or at the hospital’s outpatient clinics.
The protocol of the newborn tests when there is known maternal infection during pregnancy, but amniocentesis was not performed
The tests are performed if there is a suspected maternal CMV infection or with the recommendation of an infectious diseases specialist.
Newborn saliva/urine test when there is known negative amniocentesis
Not routinely
The follow-up and treatment protocol of asymptomatic CMV children:
Until what age is follow-up conducted?
No information received
What tests are performed in the protocol and how frequently?
No information received
The follow-up and treatment protocol of symptomatic CMV children:
Until what age is follow-up conducted?
No information received
What tests are performed in the protocol and how frequently?
No information received
Duration of drug therapy
No information received
Postnatal Diagnosis Protocol:
Type of newborn test to identify infection
Urine test.
The protocol of the newborn tests when there is known infection in amniotic fluid
During hospitalization, the following are performed: Blood tests, brain ultrasound, eye fundus examination, BERA test.
The protocol of the newborn tests when there is known maternal infection during pregnancy, but amniocentesis was not performed
Yes
Newborn saliva/urine test when there is known negative amniocentesis
In most cases, yes.
The follow-up and treatment protocol of asymptomatic CMV children:
Until what age is follow-up conducted?
No information received
What tests are performed in the protocol and how frequently?
No information received
The follow-up and treatment protocol of symptomatic CMV children:
Until what age is follow-up conducted?
No information received
What tests are performed in the protocol and how frequently?
No information received
Duration of drug therapy
No information received
Postnatal Diagnosis Protocol:
Type of newborn test to identify infection
Urine test.
The protocol of the newborn tests when there is known infection in amniotic fluid
During hospitalization, the following are performed: Blood tests, brain ultrasound, eye fundus examination, BERA test. Examination by specialists in the pediatric infectious diseases unit during hospitalization or within 3 weeks of the birth at the pediatric clinics.
The protocol of the newborn tests when there is known maternal infection during pregnancy, but amniocentesis was not performed
Continue hospitalization until the result of the urine tests is received, and if it is positive, all the tests are performed.
Newborn saliva/urine test when there is known negative amniocentesis
Yes
The follow-up and treatment protocol of asymptomatic CMV children:
Until what age is follow-up conducted?
No information received
What tests are performed in the protocol and how frequently?
No information received
The follow-up and treatment protocol of symptomatic CMV children:
Until what age is follow-up conducted?
No information received
What tests are performed in the protocol and how frequently?
No information received
Duration of drug therapy
No information received
No information received
No information received
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